|
Number
|
Deliverable Title
|
WP
|
Lead Partner
|
Person
months
|
Nature
|
Dissemination
Level
|
Delivery
Date
|
|
D1.1
|
Signed Consortium Agreement
|
1
|
1
|
3
|
O
|
PP
|
0
|
|
D1.2
|
Appointment of Project Management
|
1
|
1
|
3
|
O
|
PU
|
1
|
|
D1.3
|
Establishment of membership of all committees
|
1
|
1
|
1
|
O
|
PU
|
3
|
|
D1.4
|
Establishment of meeting timetables and locations
|
1
|
1
|
3
|
O
|
PU
|
3
|
|
D1.5
|
Annual reports to EC
|
1
|
1
|
12
|
R
|
PU
|
13,25,37
|
|
D1.6
|
Annual audit of partner expenditure
|
1
|
1
|
12
|
R
|
PU
|
13,25,37
|
|
D1.7
|
Annual review of expenditure
|
1
|
1
|
12
|
R
|
PU
|
13,25,37
|
|
D2.1
|
Report of literature review
|
2
|
14
|
6
|
R
|
PU
|
12
|
|
D2.2
|
Report on ethical practise in the consortium
|
2
|
14
|
6
|
R
|
PU
|
12
|
|
D3.1
|
Phase II DNA samples at genotyping centres (CNG & GSF)
|
3
|
3
|
6
|
O
|
CO
|
3
|
|
D3.2
|
Phase II phenotypic and environmental data at data centre
(Oxford)
|
3
|
3
|
6
|
0
|
CO
|
3
|
|
D3.3
|
Phase II genotypes to data centre
|
3
|
3
|
2
|
O
|
CO
|
12
|
|
D3.4
|
Phase II genotypes to local centres
|
3
|
3
|
2
|
O
|
CO
|
12
|
|
D3.5
|
Phase III DNA samples at CNG and GSF
|
3
|
3
|
12
|
O
|
CO
|
9
|
|
D3.6
|
Phase III Phenotypic and environmental data at Oxford
|
3
|
21
|
12
|
O
|
CO
|
9
|
|
D4.1
|
Development of common protocols for recruitment of rural
and alpine study population
|
4
|
8
|
6
|
O
|
PU
|
3
|
|
D4.2
|
Development of screening questionnaire for participation
bias
|
4
|
8
|
6
|
O
|
PU
|
6
|
|
D4.3
|
Data entry mask for rural study questionnaire, serum IgE, bronchial challenge and throat swabs
|
4
|
8
|
6
|
O
|
CO
|
6
|
|
D4.4
|
Establishment for quality control of rural data handling
|
4
|
8
|
6
|
0
|
CO
|
12
|
|
D4.6
|
Establishment of protocols for characterisation of adults
and children with severe asthma
|
4
|
1
|
3
|
0
|
PU
|
3
|
|
D4.8
|
DNA samples from case-control clinic asthmatics
|
4
|
2
|
48
|
0
|
CO
|
12
|
|
D5.1
|
Acceptance and QT checking of all DNA samples at CNG &
GSF
|
5
|
3
|
12
|
0
|
CO
|
9
|
|
D5.2
|
Whole genome association genotyping (Phase 1) complete
|
5
|
3
|
24
|
0
|
CO
|
6
|
|
D5.3
|
Phase II genotyping complete
|
5
|
3
|
24
|
0
|
CO
|
6
|
|
D5.4
|
Phase III genotyping complete
|
5
|
3
|
24
|
0
|
CO
|
18
|
|
D5.5
|
Proteomic examination of plasma asthmatics and controls
|
5
|
2
|
4
|
0
|
CO
|
18
|
|
D5.6
|
Proteomic examination of plasma farmers and controls
|
5
|
2
|
4
|
0
|
CO
|
18
|
|
D5.9
|
Database for phenotypes and genotypes
|
5
|
21
|
3
|
0
|
CO
|
6
|
|
D5.10
|
Whole genome data analysed
|
5
|
1
|
6
|
R
|
PU
|
9
|
|
D5.11
|
Joint Phase II data analysed
|
5
|
21
|
3
|
O
|
PU
|
15
|
|
D6.1
|
Detailed protocols for initial field study
|
6
|
2
|
6
|
O
|
PU
|
6
|
|
D6.2
|
Microbial components of dust samples from validation study
|
6
|
8
|
6
|
O
|
PU
|
12
|
|
D6.3
|
Components of milk samples from validation study
|
6
|
8
|
6
|
O
|
PU
|
12
|
|
D6.4
|
Revised protocols for full survey
|
6
|
2
|
6
|
O
|
PU
|
15
|
|
D7.1
|
Establishment of baseline genomic epithelial model
|
7
|
1
|
12
|
O
|
PU
|
18
|
|
D7.3
|
Establishment of Dendritic Cell
Th1 modulation model
|
7
|
13
|
12
|
O
|
CO
|
15
|
|
D8.1
|
Development of agonists and antagonists for Toll-like
receptors
|
8
|
24
|
24
|
O
|
CO
|
18
|
|
D8.3
|
Completed recruitment of pharmacogenetic
study population
|
8
|
23
|
36
|
O
|
CO
|
18
|
|
D8.5
|
Selection of target from the results of WP3 and WP5
|
8
|
27
|
6
|
O
|
CO
|
3
|
|
D8.6
|
Development of potential biotherapeutics
against target
|
8
|
27
|
36
|
O
|
CO
|
15
|
|
D9.1
|
Call for three 3 year PhD studentships
|
9
|
20
|
3
|
O
|
PU
|
3
|
|
D9.2
|
Appointment of PhD studentships
|
9
|
20
|
3
|
O
|
PU
|
6
|
|
D9.3
|
Call for 3-month visiting fellowships
|
9
|
20
|
3
|
